Read e-book online Blood-Brain Barrier in Drug Discovery: Optimizing Brain PDF

By Li Di,Edward H. Kerns

ISBN-10: 1118788354

ISBN-13: 9781118788356

Focused on imperative fearful procedure (CNS) drug discovery efforts, this publication educates drug researchers concerning the blood-brain barrier (BBB) to allow them to have an effect on vital advancements in a single of the main major – and such a lot difficult – parts of drug discovery.

• Written by means of global specialists to supply useful strategies to extend mind penetration or reduce CNS side-effects
• Reviews state of the art in silico, in vitro, and in vivo instruments to evaluate mind penetration and complex CNS drug supply strategies
• Covers BBB body structure, medicinal chemistry layout ideas, loose drug speculation for the BBB, and shipping mechanisms together with passive diffusion, uptake/efflux transporters, and receptor-mediated processes
• Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK)
• Discusses case stories of winning CNS and non-CNS medicines, classes realized and paths to the market

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Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs by Li Di,Edward H. Kerns


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